Several family studies have provided evidence for familial resemblance of pulmonary function measures. Studies have consistently shown significant parent-offspring and sibling-sibling correlations in lung volume and flow rate measures. Genetic factors may have different influences on phenotypes of airway function, lung volume, and airway-parenchymal dysanapsis. Aetiological heterogeneity may exist in families with COPD or asthma and heredity may have different effects on normal airway function and on airway dysfunction. Genetics, lifestyle and environmental factors play a role in the development of lung diseases.

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