Stem cells have been applied in the treatment of serious diseases like cancers, when requires high dose chemotherapy by extracting the patient’s own stem cells from bone marrow or peripheral blood  After the treatment extracted stem cells were stored temporarily and transplanted in order to minimize the side effects of aggressive chemotherapy which helps to support the regeneration of destroyed cells  Stem cell therapy have been applied successfully for Hematopoietic disorders, Immunodeficiency, Metabolic disorders, Autoimmune diseases, Cancers, Graft-versus-host disease (GvHD), Impairments of the brain, Cardiovascular diseases, Multiple sclerosis, Amyotrophic lateral sclerosis, Autism, Hearing loss, Cirrhosis of the liver, HIV and Epidermolysis bullosa